Synthesis of bioactive and stabilized cyclic peptides by macrocyclization using C(sp3)–H activation† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c6sc05530c Click here for additional data file.

Rhodium(i)-catalyzed stereoselective [4+2] cycloaddition of oxetanols with alkynes through C(sp3)–C(sp3) bond cleavage† †Electronic supplementary information (ESI) available. CCDC 1512439 and 1512440. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6sc05246k Click here for additional data file. Click here for additional data file.

Rh(iii)-catalyzed double C–H activation of aldehyde hydrazones: a route for functionalized 1H-indazole synthesis† †Electronic supplementary information (ESI) available. CCDC 1499990. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6sc03888c Click here for additional data file. Click here for additional data file.

Synthesis of bioactive and stabilized cyclic peptides by macrocyclization using C(sp3)-H activation.

Cyclic peptides have attracted increasing attention in recent years due to their ability to inhibit protein-protein interactions. Current strategies to prepare cyclic peptides often rely on functional amino acid side chains or the incorporation of unnatural amino acids, thus limiting their structural diversity. Here, we describe the development of a highly versatile peptide macrocyclization str...

Intermolecular oxidative decarbonylative [2 + 2 + 2] carbocyclization of N-(2-ethynylaryl)acrylamides with tertiary and secondary alkyl aldehydes involving C(sp3)–H functionalization† †Electronic supplementary information (ESI) available. CCDC 1438591. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6sc02451c Click here for additional data file. Click here for additional data file.

Room temperature C(sp2)–H oxidative chlorination via photoredox catalysis† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc03010j Click here for additional data file.

Photoredox catalysis has been developed to achieve oxidative C-H chlorination of aromatic compounds using NaCl as the chlorine source and Na2S2O8 as the oxidant. The reactions occur at room temperature and exhibit exclusive selectivity for C(sp2)-H bonds over C(sp3)-H bonds. The method has been used for the chlorination of a diverse set of substrates, including the expedited synthesis of key in...